Thursday, March 20, 2014

The effect of obesity on antibiotic treatment failure: a historical cohort study.

PURPOSE: Obesity is an important risk factor for infections. Is obesity related to antibiotic treatment failure (ATF)?

METHODS: 6179 patients were evaluated. ATF was defined as any additional antibiotic prescriptions or hospitalizations for infections within the 30 days after initial therapy.

RESULTS: In the patient sample, 39% were overweight and 21% were obese. ATF occurred in 13% of the patients. Obesity was a significant predictor of ATF (adjusted OR 1.26).

CONCLUSION: Obesity is a significant risk factor for antibiotic treatment failure. This association may be due to the current "one size fits all" dosing strategy, in which adults get the same dose of antibiotic regardless of body weight.

Pharmacoepidemiol Drug Saf. 2013 Sep;22(9):970-6

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